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KMID : 0355220160410030091
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Journal of Korean Academy Oral Medicine
2016 Volume.41 No. 3 p.91 ~ p.98
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Oral Lichen Planus and Oral Lichenoid Lesion: Diagnosis and Assessment of Direct Immunofluorescence
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Lee Kyung-Eun
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Abstract
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Purpose: Oral lichen planus (OLP) has generated many discussions and been associated with much controversy for a long time. A reliable diagnosis of OLP has proven challenging and significant disagreements concerning its diagnosis has continued. Therefore, the aim of this study was to apprehend newly proposed diagnostic criteria of OLP and oral lichenoid lesion (OLL) and to evaluate difference of final diagnosis of OLP and OLL in accordance with type of diagnostic criteria. Also, direct immunofluorescence (DIF) was compared to evaluate the value of DIF between two groups.
Methods: Fifty-two patients with DIF result were retrospectively reviewed. The selected patients were classified by the modified World Health Organization (WHO) diagnostic criteria of OLP and OLL and by criteria proposed by American Academy of Oral and Maxillofacial Pathology (AAOMP). Results of DIF in OLP and OLL were classified by deposition intensity or pattern of fibrinogen. The classification of fluorescence pattern in each specimen was graded as positive, possibly positive or negative.
Results: Patients diagnosed as OLP were a few more when the modified WHO diagnostic criteria were used than when criteria proposed by AAOMP were used. There was no statistical difference of DIF between OLP and OLL by applying the WHO modification criteria or criteria proposed by AAOMP.
Conclusions: The final diagnosis of OLP could be changed in accordance with type of diagnostic criteria and difference of DIF between OLP and OLL was not found.
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KEYWORD
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Criteria, Direct immunofluorescence, Fibrinogen, Fluorescent antibody technique, Lichen planus, oral, Oral lichenoid lesion
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